A basic premise of this book is that while it is important to review and examine what is known, it is just as important to consider what is not known and frame questions for future development in our never-ending quest to preserve and restore vision. 

Before you can seek the answers you must understand and appreciate the questions. This book strives to do much of the former and even more of the latter.

– D. Jackson Coleman , MD & Harvey A. Lincoff, MD 

– New York, NY



The vitreous body long has been the most mysterious of all ocular structures, owing perhaps to its seeming simplicity. There have been few concerted, sustained efforts to unravel the mysteries of how vitreous is composed and what role it plays in normal physiology as well as pathology. Over the years, however, many studies have produced important findings concerning vitreous biochemistry, structure, physiology, and pathobiology. Published on the 25th anniversary of Sebag’s first book on Vitreous, this second installment is nearly five times longer than its predecessor, reflecting how much has been learned in the past quarter century. This well-constructed compendium not only addresses the most current scientific knowledge, but also reviews clinical perspectives in a manner that lends richness to the scope of the book.

Written by 90 authors, this book has 56 chapters organized into 7 sections: Biochemistry; Anatomy, Development, and Aging; Pathology/Pathobiology; Physiology and Phamacotherapy; Posterior Vitreo-Retinal Surgery; Peripheral Vitreo-Retinal Surgery; and Pharmacologic Vitreolysis. With a foreword by Coleman & Lincoff and an introduction by Wallace Foulds, Sebag’s latest tome on vitreous is destined to be the authoritative text for years to come.



 What’s Inside

  • In-depth presentation of vitreous biochemistry, molecular organization, morphology, physiology, and pathobiology 
  • Role of vitreous in ocular disorders analyzed in terms of molecular and cell biology, abnormal physiology, and anomalies in development and aging 
  • Enhanced diagnostics described with modern imaging including advanced ultrasonography and swept source OCT imaging 
  • The history and future of vitrectomy are presented with accompanying videos of vitreo-retinal surgery 
  • 10 chapters on Pharmacologic Vitreolysis
  • Extensive cross-referencing enables navigation from chapter to chapter, as well as instantaneous access to figures and videos 
New perspectives on: 
– developing an artificial vitreous
– imaging the invisible vitreous
– role of hyalocytes in health and disease
– role of vitreo-papillary adhesion/traction
– oxygen physiology in neovascularization & cataracts
– surgical innovations employing chromodissection,
retinectomy, robotics & virtual reality,
pneumatic retinopexy, timing of re-operations,
endovascular surgery
– impact and management of floaters
– present & future pharmacotherapy




J. Sebag (Ed.)
Vitreous in Health and Disease

2014, XXVIII, 925 p. 520 illus., 359 illus. in




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